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概覽詳細(xì)介紹

曹登峰主任醫(yī)師

北京大學(xué)腫瘤醫(yī)院病理科

執(zhí)業(yè)經(jīng)歷

曹登峰，男，教授，主任醫(yī)師，博士生導(dǎo)師, 病理科主任，病理教研室主任，北京市2012年海外高層次人才計(jì)劃(海聚計(jì)劃)入選者。 1988年就讀于北京協(xié)和醫(yī)學(xué)院8年制臨床醫(yī)學(xué)專業(yè)，1996年畢業(yè)獲得醫(yī)學(xué)博士學(xué)位(M.D.)，同年赴美留學(xué)，2001年美國(guó)University Of Pittsburgh分子發(fā)育細(xì)胞生物學(xué)博士研究生畢業(yè)，獲得理學(xué)博士學(xué)位(Ph.D.)。 2001年-2005年在美國(guó)約翰霍普金斯大學(xué)醫(yī)學(xué)院附屬約翰霍普金斯醫(yī)院(The Johns Hopkins Hospital，該院一直是美國(guó)排名第1到2名的綜合醫(yī)院) 病理學(xué)系做住院醫(yī)生(resident in anatomic and clinical pathology)，期間表現(xiàn)突出獲得Joseph Eggleston外科病理學(xué)獎(jiǎng)。2005-2006年在約翰霍普金斯醫(yī)院病理系在世界著名的泌尿生殖病理學(xué)家Dr. Jonathan Epstein(2004年《世界衛(wèi)生組織泌尿系統(tǒng)和男性生殖器官腫瘤病理學(xué)和遺傳學(xué)》主編之一)的指導(dǎo)下從事外科病理高級(jí)亞?？朴?xùn)練, 同時(shí)強(qiáng)化泌尿系統(tǒng)和男性生殖系統(tǒng)病理的學(xué)習(xí)。在2001-2006年期間，還跟隨世界著名的胰腺病理學(xué)家Dr. Ralph Hruban (2010年《世界衛(wèi)生組織消化系統(tǒng)腫瘤分類》的主編之一) 系統(tǒng)地學(xué)習(xí)胰腺病理。2006-2007年在美國(guó)約翰霍普金斯醫(yī)院病理系跟隨世界著名的婦科病理學(xué)家Dr. Robert Kurman (婦產(chǎn)科病理《Blaustein’s Pathology of the Female Genital Tract》的主編， 2013年《世界衛(wèi)生組織婦科腫瘤分類》的主編之一)系統(tǒng)地學(xué)習(xí)婦產(chǎn)科病理。 2007-2011和2012年6-8月在美國(guó)圣.路易斯華盛頓大學(xué)醫(yī)學(xué)院(Washington University School of Medicine in Saint Louis)& 巴恩斯-猶太人醫(yī)院(Barnes-Jewish Hospital，2012年美國(guó)綜合醫(yī)院排名第六)病理系擔(dān)任病理醫(yī)生(attending pathologist), 助理教授(assistant professor)，副教授(associate professor), 從事外科和婦產(chǎn)科臨床病理的診斷，教學(xué)和科研，提供婦產(chǎn)科和泌尿生殖系統(tǒng)及胰腺疑難病理的會(huì)診，指導(dǎo)和訓(xùn)練病理住院醫(yī)生和亞?？撇±磲t(yī)生，同時(shí)任免疫組織化學(xué)科研實(shí)驗(yàn)室主任。 2011年8月歸國(guó)擔(dān)任北京大學(xué)腫瘤醫(yī)院病理科主任，教授，主任醫(yī)師，博士生導(dǎo)師，病理教研室主任，2012年入選北京市海外高層次人才計(jì)劃(海聚計(jì)劃)。從事腫瘤病理的臨床診斷，教學(xué)和科研工作。臨床病理診斷專長(zhǎng)是腫瘤病理，提供腫瘤疑難病理的會(huì)診,特別擅長(zhǎng)婦產(chǎn)科病理，泌尿系統(tǒng)病理，生殖細(xì)胞腫瘤病理和胰腺病理?？蒲蟹矫鎻氖履[瘤病理的形態(tài)學(xué), 發(fā)病機(jī)理和腫瘤標(biāo)志物的研究，已經(jīng)發(fā)表56篇SCI論文，在世界上首先發(fā)現(xiàn)SALL4是最敏感的生殖細(xì)胞腫瘤標(biāo)志物，并系統(tǒng)地研究了另外一個(gè)生殖細(xì)胞腫瘤標(biāo)志物L(fēng)IN28，使生殖細(xì)胞腫瘤特別是卵黃囊瘤的病理診斷難題得以最后解決。曹登峰教授目前是4家國(guó)際學(xué)術(shù)雜志的編委會(huì)專家(editorial board member)，中華病理學(xué)會(huì)女性生殖系統(tǒng)病理專業(yè)學(xué)組專家，美國(guó)病理學(xué)會(huì)(College of American Pathologists)和國(guó)際泌尿病理學(xué)會(huì)(International Association of Urologic Pathology)的高級(jí)會(huì)員(fellow)，美國(guó)加拿大病理學(xué)會(huì)(United States and Canadian Academy of Pathology)會(huì)員，國(guó)際華人病理協(xié)會(huì)(International Association of Chinese Pathologists)會(huì)員，2010-2011年曾任國(guó)際華人病理協(xié)會(huì)主席。發(fā)表的科研論文(截至2012年7月)： 1.Kunkel J, Peng Y, Tao Y, Krigman H, Cao D. Presence of sarcomatous component outside the ovary is an adverse prognostic factor for primary ovarian mixed mesodermal tumor: a clinicopathologic study of 47 cases. Am J Surg Pathol. 2012;36(6):831-7. 2.Hamilton NA, Liu TC, Cavatiao A, Mawad K, Chen L, Strasberg SS, Linehan DC, Cao D, Hawkins WG. Ki-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasms. Surgery. 2012;152(1):107-13. 3.Hudson J, Cao D, Vollmer RD, Humphrey PA. Foamy Gland Adenocarcinoma of the Prostate: Incidence, Gleason Grade, and Early Clinical Outcome. Hum Pathol. 2012;43(7):974-9 4.Wang-Gillam A, Ben-Josef E, Cao D, Chung E, Khan A, Lim KH, Linehan DC. Neoadjuvant Therapy of Pancreatic Cancer: The Emerging Paradigm? Oncologist. 2012;17(2):192-200. 5.Xu M, Rettig M, Sudlow G, Wang B, Akers W, Cao D, Mutch D, Dipersio J, Achilefu S. I Preclinical evaluation of mab CC188 for ovarian cancer imaging. Int J Cancer. 2011 Nov 30. doi: 10.1002/ijc.27380. [Epub ahead of print] 6.Iczkowski KA, Montironi R, Cao D, Magi-Galluzzi C, Lucia MS. Pathology update for urologists. Prostate Cancer. 2011;2011:183761. 7.Abbosh PH, Grubb RL III, Cao D, Humphrey PA. Hybrid Renal Tumors in Birt-Hogg-Dubé Syndrome. J Urol. 2011;186(6):2413-4. 8.Cao D, Zhang J, Wu Z, Qiu G. Calcitonin Enhanced Lumbar Spinal Fusion in a New Zealand Rabbit Model: A Study with Morphologic and Molecular Analysis. 9.Cao D, Humphrey PA. Yolk Sac Tumor of the Testis.J Urol. 2011;186(4):1475-6. 10.Xue D, Peng Y, Wang F, Allan RW, Cao D. RNA-binding protein LIN28 is a sensitive immunohistochemical marker of ovarian primitive germ cell tumors. Histopathology 2011;59：452–459. 11.Jeung JA, Cao D, Selli BW, Clapp WL, Oliai BR, Parwani AV, Allan RW. Primary Renal Carcinoid Tumors: Evaluation of PAX-2 and PAX-8 Expression with Emphasis on Novel Immunohistochemical Findings. Human Pathol. 2011;42(10):1554-61. 12.曹登峰，霍麗明，王鵬。美國(guó)病理住院醫(yī)師培訓(xùn)的經(jīng)驗(yàn)和借鑒。中華病理學(xué)雜志，2011年第40卷第6期第430-432頁(yè)。 13.Cao DHumphrey PA,Gao F, Tao Y, Kibel AS. The linear length of positive margin in radical prostatectomy is predictive of biochemical recurrence in patients with prostate cancer. Urology. 2011;77(6):1409-14. , 14.Cao D, Allan RW, Cheng L, Peng Y, Guo CC, Dahiya N, Akhi S, Li J. RNA-binding protein Lin28 is a marker for testicular germ cell tumors. Hum Pathol. 2011:42(5):710-8. 15.Cao D, Liu A, Wang F, Allan RW, Mei K, Peng Y, Du J, Guo S, Abel TW, Lane Z, Ma J, Rodriguez M, Akhi S, Dahiya N, Li J. RNA-binding protein Lin28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases. Mod Pathol. 2011;24(2):288-96. 16.Han S, Cao D, Molberg KH, Sarode V, Rao R, Sutton LM, Peng Y. Hormone Receptor Status Rather Than HER-2 Status is Significantly Associated with Increased Ki67 and p53 Expression in Triple-Negative Breast Carcinomas, and High Expression Level of Ki67 but not p53 is Significantly Associated with Axillary Nodal Metastasis in Triple-Negative and High Grade Non-Triple Negative Breast Carcinomas. Am J Clin Pathol. 2011;135(2):230-7. 17.SuttonLM, HanJS, MolbergKH, SarodeVR, Cao D, SailorsJ, PengY. Intratumoral Expression Level of Epidermal Growth Factor Receptor and Cytokeratin 5/6 is Significantly Associated with Nodal and Distant Metastases in Patients with Basal-like Triple-negative Breast Carcinoma. Am J Clin Pathol. 2010;134(5):782-7. 18.Wang P, Li J, Allan RW, Guo CC, Peng Y, Cao D. Expression of UTF1 in primary and metastatic testicular germ cell tumors. Am J Clin Pathol. 2010;134 (4):604-612. 19.Cao DVoller RT, Luly J, Jain S, Roytman TM, Ferris CW, Hudson MA. Comparison of 2004 WHO and 1973 WHO Grading Systems for Predicting Long-term Prognosis in Urothelial Carcinoma (UC) Patients. Urology. 2010;76(3):593-9., 20.Cao D, Lane Z, Allan RW, Wang P, Guo CC, Li J. TCL1 is a novel diagnostic marker for intratubular germ cell neoplasia and classic seminoma. Histopathology 2010;57(1):152-7. 21.Lindberg MR, Fisher C, Cao D, Cheville JC, Folpe AL. Leiomyosarcoma of the urinary bladder: a clinicopathologic study of 34 cases, with comparison of the FNCLCC, NCI, and Mayo grading systems. J Clin Pathol. 2010;63(8):708-13. 22.Shi H, Cao D, Wei L, Sun L, Guo A. Inflammatory angiomyolipomas of the liver: aclinicopathologic and immunohistochemical analysis of five cases. Ann Diagn Pathol. 2010;14(4):240-6. 23.Cao D, Kibel AS, Gao F, Tao Y, Humphrey PA. The Gleason score of tumor at themargin in radical prostatectomy is predictive of biochemical recurrence. Am J Surg Pathol. 2010;34(7):994-1001. 24.Shi H, Wang Chun, Wei L,Sun L, Cao D. Malignant mesenchymoma of the thyroid: one case report and literature review. Tumori 2010;96: 345-348. 25.Liu A, Cheng L, Du J, Peng Y, Allan RW, Wei L, Li J, Cao D. Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primarymediastinal germ cell tumors. Am J Surg Pathol. 2010;34(5):697-706. 26.Yaskiv O, Cao D, Humphrey PA. Microcystic adenocarcinomas of the prostate: a variant of pseudohyperplastic and atrophic patterns. Am J Surg Pathol.2010 ;34(4):556-61 27.Cao DBegum S, Ali SZ, Westra WH. Expression of P16 in benign and malignant cystic squamous lesions of the neck. Hum Pathol. 2010;41(4):535-9., 28.Shi H, Cao D, Wei L, Sun L, Guo A. Primary choriocarcinoma of the liver: a clinicopathologic study of 5 cases in males. Virchows Arch. 2010;456(1):65-70 29.Mei K, Liu A, Allan RW, Wang P, Lane Z, Abel TW, Wei L, Cheng H, Guo S, Peng Y, Rekheja D, Wang M, Ma J, Rodriguez M, Li J, Cao D. Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases. Mod Pathol. 2009; 22(12): 1628-36. 30.Wang F, A Liu, Peng Y, Rakheja D, Wei L, Xue D, Allan RW, Molberg KH, Li J, Cao D. Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alpha-fetoprotein, and glypican-3. Am J Surg Pathol. 2009; 33(10): 1529-1539. 31.Kibel AS, Dehdashti F, Matthew K, Aleksandra K, Robert L Grubb, Humphrey P, Siegel C, Cao D, Gao F, Siegel BA. Prospective Study Of Fdg- Pet/Ct For Staging Of Muscle-Invasive Bladder Carcinoma. J Clin Oncol. 2009; 27(26): 4314-20. 32.Cao D, Li J, Guo CC, Allan RW, Humphrey PA. SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol. 2009; 33: 1065-1077. 33.Cao D, Humphrey PA, Allan RW. SALL4 is a novel sensitive and specific marker of metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumor. Cancer. 2009; 115(12): 2640-51. 34.Cao D, Guo S, Allan RW, Molberg KH, Peng Y. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol. 2009; 3(6): 894-904. 35.Arroyo M, Podda A, Cao D, Rodriguez M. Placental Site Trophoblastic Tumor in the Ovary of a Young Child with Isosexual Precocious Puberty. Pediatr Dev Pathol. 2009; 12(1): 73-76. 36.Cao D, PolyakK, HalushkaMK, NassarH, KouprinaN, Iacobuzio-DonahueC, WuX, SukumarS, HicksJ, De MarzoA and ArganiP.Serial Analysis of Lobular Carcinoma in situ identified down of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008; 10(5): R91. 37.Cheung M and Cao D. Colonic type adenocarcinoma arising in a primary retroperitoneal mature cystic teratoma. Pathol Int. 2008; 58(12): 792-6. 38.Cao D, Ashfaq R, Goggins MG, Hruban RH, Kern SE and Iacobuzio-Donahue CA. Differential Expression of Multiple Genes in Association with MADH4/DPC4/SMAD4 Inactivation in Pancreatic Cancer. Int J Clin Exp Pathol 2008; 1(6): 510-517. 39.Lollar K, Farrag TY, Cao D, Niparko J, Tufano RP. Langerhans cell histiocytosis of the thyroid gland. Am J Otolaryngol. 2008; 29(3): 201-4. 40.Cao D, Tsangaris TN, Kouprina N, Vang R, Argani P. The Superficial Margin of the Skin-Sparing Mastectomy for Breast Carcinoma: Factors Predicting Involvement and Efficacy of Additional Margin Sampling. Ann Surg Oncol. 2008; 15(5): 1330-40 41.Lai V, Farrag TY, Cao D, Aygun N, Boahene K, Tufano RP. Synovial sarcoma of the infratemporal fossa. Am J Otolaryngol. 2007; 28(6): 444-7. 42.Lee KM, Cao D (co-first authorship), Itami A, Pour PM, Hruban RH, Maitra A, Ouellette MM. Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia. Histopathology. 2007; 51(4): 539-46. 43.Cao D, Zhang Q, Wu LS, Salaria SN, Winter JW, Hruban RH, Goggins MS, Abbruzzese JL, Maitra A, Ho L. Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. Mod Pathol. 2007; 20(5): 570-8. 44.Cao D, Antonescu C, Wong G, Winter J, Maitra A, Adsay NV, Klimstra DS, Hruban RH. Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations. Mod Pathol. 2006; 19(9): 1157-63. 45.Cao D, Lin C, Woo SH, Vang R, Tsangaris T and Argani P. Separate Cavity Margin Sampling At The Time of Initial Breast Lumpectomy Significantly Reduces The Need For Re-excisions. Am J Surg Pathol. 2005; 29 (12): 1625-32. 46.Cao D, Wilentz R, Abbruzzese J, Ho L and Maitra A. Aberrant expression of maspin in idiopathic inflammatory disease is associated with disease activity and neoplastic transformation. Int J Gastrointest Cancer. 2005; 36(1): 39-46. 47.Begum S, Cao D and Westra W. Tissue distribution of HPV 16 DNA integration in patients with tonsillar carcinoma as visualized by HPV 16 in situ hybridization and p16 immunohistochemistry. Clin Cancer Res. 2005; 11 (16): 5694-9. 48.Cao D, Maitra A, Saavedra JA, Klimstra DS and Hruban RH. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms-additional evidence of different genetic pathways. Mod Pathol. 2005; 18 (6): 752-61. 49.Cao D, Srodon M, Montgomery EA and Kurman RJ. Lipomatous variant of angiomyofibroblastoma-report of two cases and review of the literature. Int J Gynecol Pathol. 2005; 24(2): 196-200. 50.Cao D, Hafez M, Berg K and Epstein JI. Little or no residual cancer on radical prostatectomy following diagnosis of cancer on needle biopsy-vanishing cancer or switched specimens? A microsatellite analysis of biopsy and radical prostatectomy specimen identity. Am J Surg Pathol. 2005; 29(4): 467-473. 51.Cao D, Ji H and Ronnett BM. Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumor from metastatic pancreatic mucinous carcinomas in ovary. Int J Gynecol Pathol. 2005; 24(1): 67-72. 52.Singer G, Stohr R, Cope L, Dehari R, Hartmann A, Cao DF, Wang TL, Kurman RJ and Shih IM. Patterns of p53 Mutations Separate Ovarian Serous Borderline Tumors and Low- and High-grade Carcinomas and Provide Support for a New Model of Ovarian Carcinogenesis: A Mutational Analysis With Immunohistochemical Correlation. Am J Surg Pathol. 2005; 29(2): 218-224. 53.Cao D, Hustinx S, Sui S, Bala P, Sato N, Martin S, Maitra A, Murphy KM, Cameron JL, Yeo CY, Kern SE, Goggins M, Pandey A, and Hruban RH. Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags. Cancer Biol Ther. 2004; 3(11): 1081-9. 54.Hustinx S, Cao D, Sato N, Martin S, Fukushima N, Maitra A, Cameron JL, Yeo CY, Kern SE, Goggins M, Pandey A, and Hruban RH. Identification of novel differentially expressed gene in pancreatic ductal adenocarcinoms through serial analysis of gene expression. Cancer Biol Ther. 2004; 3(12): 1254-1261. 55.Parwani A, Cao Dand Epstein JI. Pathology quiz case: a 35 year-old man with hematuria. Arch Pathol Lab Med. 2004; 128(8): e104-6. . 56.Wang LF, Zhu HD, Miao SY, Cao DF, Wu YW, Zong SD and Koide SS. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. Arch Androl. 1999; 42(2): 71-84. 57.高穎，朱海東，曹登峰，盛齊，繆時(shí)英，王琳芳。一種新的睪丸特異核孔蛋白基因特性的研究。中國(guó)醫(yī)學(xué)科學(xué)院學(xué)報(bào)1999年第21卷第02期第81-87頁(yè)。 58.張梅林, 周雪峰, 曹登峰, 繆時(shí)英, 吳燕婉, 邢志軍, 宗書東, 王琳芳. 一種與不育有關(guān)的人精子蛋白質(zhì)的組織特異性及表達(dá). 中國(guó)醫(yī)學(xué)科學(xué)院學(xué)報(bào), 1999年第21卷第03期第166-169頁(yè)。